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While heartburn (gastroesophageal reflux) is not specifically listed among the most common adverse effects in semaglutide's FDA labeling, related symptoms such as dyspepsia (indigestion) and eructation (belching) are documented side effects, particularly with Wegovy

And, losing weight can help mitigate some of the hormonal irregularities that come with PCOS, says Karen Tang, MD, an OB-GYN and founder of Thrive Gynecology